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Targeted Allele Detail
Symbol: Flt1tm1Jrt
Name: FMS-like tyrosine kinase 1; targeted mutation 1, Janet Rossant
MGI ID: MGI:1857717
Synonyms: Flt-1-, Flt-1lacZ, Flt1lacZ, flt-1lcz, VEGFR1-lacZ
Gene: Flt1  Location: Chr5:147561604-147726011 bp, - strand  Genetic Position: Chr5, 87.01 cM, cytoband G
Germline Transmission:  Earliest citation of germline transmission: J:26845
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA LacZ-neomycin resistance cassette replaced sequences that encode the signal peptide. The authors predict this is a null allele because the translation start site is removed and reinitiation at the first two downstream Kozak sequences would result in out-of-frame translated products. (J:26845)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 89 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Flt1 Mutation:  5 strains or lines available
Original:  J:26845 Fong GH, et al., Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995 Jul 6;376(6535):66-70
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory