All Phenotypes Flt1<tm1Jrt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Flt1^tm1Jrt
targeted mutation 1, Janet Rossant
MGI:1857717

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flt1^tm1Jrt/Flt1^tm1Jrt	either: (involves: 129/Sv) or (involves: CD-1) or (involves: ICR)	MGI:2169030
hm2	Flt1^tm1Jrt/Flt1^tm1Jrt	involves: 129S1/Sv * 129X1/SvJ	MGI:4844277
ht3	Flt1^tm1Jrt/Flt1⁺	involves: CD-1	MGI:4844286
ht4	Flt1^tm1Jrt/Flt1⁺	Not Specified	MGI:4844291
ht5	Flt1^tm1Jrt/Flt1^tm1.2Fong	involves: 129 * C57BL/6NCr * CD-1	MGI:5523780
cx6	Akt1^tm1Mbb/Akt1⁺ Flt1^tm1Jrt/Flt1⁺	involves: 129P2/OlaHsd	MGI:4844292
cx7	Dmd^mdx-5Cv/Dmd^mdx-5Cv Flt1^tm1Jrt/Flt1⁺ Utrn^tm1Jrs/Utrn^tm1Jrs	involves: 129S1/Sv * 129X1/SvJ * C3HA * C57BL/6Ros	MGI:4844311
cx8	Dmd^mdx-5Cv/Dmd^mdx-5Cv Flt1^tm1Jrt/Flt1⁺	involves: C3HA * C57BL/6Ros	MGI:4844310

Allelic Composition	Flt1^tm1Jrt/Flt1^tm1Jrt
Genetic Background	either: (involves: 129/Sv) or (involves: CD-1) or (involves: ICR)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1^tm1Jrt mutation (1 available); any Flt1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:54830 )

• at E7.0, mice exhibit increased number of hemangioblasts compared with wild-type mice

• at E8.5, the number of endothelial cells is increased compared to in wild-type mice

• at E8.5, mice exhibit an increase in primary erythrocytes compared with wild-type mice

• altered cell differentiation leads to increased number of hemangioblasts compared to in wild-type mice

hematopoietic system

increased hemangioblast number ( J:54830 )

• at E7.0, mice exhibit increased number of hemangioblasts compared with wild-type mice

abnormal embryonic erythrocyte morphology ( J:54830 )

• at E8.5, mice exhibit an increase in primary erythrocytes compared with wild-type mice

Allelic Composition	Flt1^tm1Jrt/Flt1^tm1Jrt
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1^tm1Jrt mutation (1 available); any Flt1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:26845 )

• no mice are observed after E9

cardiovascular system

abnormal vascular development ( J:26845 )

• only large fused vessels with internally localized groups of endothelial cells are present in the head mesenchyme instead of the small vessels observed in wild-type mice

abnormal dorsal aorta morphology ( J:26845 )

• contains endothelial cells within the lumen

abnormal vitelline vasculature morphology ( J:26845 )

• vascular structures are large and enclosed with endothelial cells compared to in wild-type mice

• however, endothelial cell formation is normal

disorganized yolk sac vascular plexus ( J:26845 )

abnormal heart development ( J:26845 )

• the endocardial lining of heart ventricles are thickened and disorganized compared to in wild-type mice

embryo

abnormal vitelline vasculature morphology ( J:26845 )

• vascular structures are large and enclosed with endothelial cells compared to in wild-type mice

• however, endothelial cell formation is normal

disorganized yolk sac vascular plexus ( J:26845 )

embryonic growth arrest ( J:26845 )

• at E8.5

abnormal visceral yolk sac blood island morphology ( J:26845 )

• blood-island structures are abnormal and disorganized compared to in wild-type mice

Allelic Composition	Flt1^tm1Jrt/Flt1⁺
Genetic Background	involves: CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1^tm1Jrt mutation (1 available); any Flt1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased response of heart to induced stress ( J:101949 )

• mice exhibit decreased ischemic preconditioning-mediated cardioprotection compared with wild-type mice

homeostasis/metabolism

increased response of heart to induced stress ( J:101949 )

• mice exhibit decreased ischemic preconditioning-mediated cardioprotection compared with wild-type mice

Allelic Composition	Flt1^tm1Jrt/Flt1⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1^tm1Jrt mutation (1 available); any Flt1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:164891 )

• mice exhibit increased vascular density in the tibialis anterior compared with wild-type mice

abnormal physiological neovascularization ( J:151369 )

• following hind limb ischemia, mice exhibit blood flow and reduced capillary density compared with similarly treated wild-type mice

increased angiogenesis ( J:164891 )

• mice exhibit increased vascular density in the tibialis anterior compared with wild-type mice

abnormal blood circulation ( J:164891 )

• mice exhibit increased blood perfusion compared with wild-type mice

Allelic Composition	Flt1^tm1Jrt/Flt1^tm1.2Fong
Genetic Background	involves: 129 * C57BL/6NCr * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1^tm1.2Fong mutation (0 available); any Flt1 mutation (73 available)
Flt1^tm1Jrt mutation (1 available); any Flt1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:202202 )

• at E8.5 as in Flt1^tm1Jrt homozygotes

Allelic Composition	Akt1^tm1Mbb/Akt1⁺ Flt1^tm1Jrt/Flt1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Mbb mutation (1 available); any Akt1 mutation (34 available)
Flt1^tm1Jrt mutation (1 available); any Flt1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:151369 )

N	• following hind limb ischemia, mice exhibit normal blood flow and capillary density

Allelic Composition	Dmd^mdx-5Cv/Dmd^mdx-5Cv Flt1^tm1Jrt/Flt1⁺ Utrn^tm1Jrs/Utrn^tm1Jrs
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3HA * C57BL/6Ros

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx-5Cv mutation (1 available); any Dmd mutation (153 available)
Flt1^tm1Jrt mutation (1 available); any Flt1 mutation (73 available)
Utrn^tm1Jrs mutation (2 available); any Utrn mutation (306 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:164891 )

• compared with Dmd^mdx-5Cv Utrn^tm1Jrs homozygotes

muscle

centrally nucleated skeletal muscle fibers ( J:164891 )

• mice exhibit fewer muscle fibers with centrally localized nuclei compared with Dmd^mdx-5Cv Utrn^tm1Jrs homozygotes

growth/size/body

increased body weight ( J:164891 )

• compared with Dmd^mdx-5Cv Utrn^tm1Jrs homozygotes

Allelic Composition	Dmd^mdx-5Cv/Dmd^mdx-5Cv Flt1^tm1Jrt/Flt1⁺
Genetic Background	involves: C3HA * C57BL/6Ros

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:164891 )

N	• mice exhibit more stable and less degenerative muscle fibers with fewer calcium deposits and reduced fibrosis in the diaphragm compared with Dmd^mdx-5Cv homozygotes

abnormal muscle development ( J:164891 )

• mice exhibit an increase in total satellite cells and myogenic precursor cells compared with Dmd^mdx-5Cv homozygotes

abnormal skeletal muscle fiber morphology ( J:164891 )

• mice exhibit an increase in the number of slow muscle fibers compared with Dmd^mdx-5Cv homozygotes

abnormal skeletal muscle fiber size ( J:164891 )

• mice exhibit less variability in skeletal muscle fiber size compared with Dmd^mdx-5Cv homozygotes

increased satellite cell number ( J:164891 )

• mice exhibit an increase in total satellite cells and myogenic precursor cells compared with Dmd^mdx-5Cv homozygotes and wild-type mice

abnormal muscle contractility ( J:164891 )

• mice exhibit improved muscle contractile function compared with Dmd^mdx-5Cv homozygotes

cardiovascular system

increased capillary density ( J:164891 )

• capillary density in the tibialis anterior muscle and diaphragm is increased compared to in Dmd^mdx-5Cv homozygotes

abnormal blood circulation ( J:164891 )

• mice exhibit increased blood perfusion compared with Dmd^mdx-5Cv homozygotes

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