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Radiation induced Allele Detail
Symbol: LnpkUl
Name: lunapark, ER junction formation factor; ulnaless
MGI ID: MGI:1857660
Synonyms: Ul
Gene: Lnpk  Location: Chr2:74350635-74409779 bp, - strand  Genetic Position: Chr2, 44.13 cM

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  (C3H/HeJ x 101/H)F1
Allele Type:    Radiation induced
Mutation:    Inversion
  LnpkUl involves 22 genes/genome features (Lnpk, Mrpl23-ps1, Evx2 ...) View all
Mutation detailsThe ulnaless mouse has been characterized as a paracentric inversion with a centromeric breakpoint into the lunapark gene and a telomeric breakpoint 770 kb away. This inversion disrupts the lunapark gene and increases the distance between the neighboring HoxD cluster and a cluster of enhancer sequences controlling several distinct genes over a large region. Genes Evx2, Hoxd12 and Hoxd13 are all misexpressed in the limb buds and genital buds of the ulnaless mouse. The inverted DNA includes Evx2, the HoxD complex, Mtx2, as well as some pseudogenes. (J:83372)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 62 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lnpk Mutation:  20 strains or lines available
Original:  J:13461 Morris T, Ul. Mouse News Lett. 1967;36:34
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory