About   Help   FAQ
Hgftm1Cbm
Targeted Allele Detail
Nomenclature
Symbol: Hgftm1Cbm
Name: hepatocyte growth factor; targeted mutation 1, Carmen Birchmeier
MGI ID: MGI:1857656
Synonyms: SF/HGF-
Gene: Hgf  Location: Chr5:16553495-16619439 bp, + strand  Genetic Position: Chr5, 7.07 cM, cytoband A2-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23170
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsDeletion of exon 2, which encodes amino acids 31 to 84 of the receptor binding domain, and replacement of these sequences with a neomycin cassette. (J:23170)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hgf Mutation:  5 strains or lines available
References
Original:  J:23170 Schmidt C, et al., Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 1995 Feb 23;373(6516):699-702
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory