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Bmp7tm1Rob
Targeted Allele Detail
Nomenclature
Symbol: Bmp7tm1Rob
Name: bone morphogenetic protein 7; targeted mutation 1, Elizabeth J Robertson
MGI ID: MGI:1857654
Synonyms: Bmp7-, BMP-7-, Bmp7m1Rob
Gene: Bmp7  Location: Chr2:172868012-172940321 bp, - strand  Genetic Position: Chr2, 95.54 cM
Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30057
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing the first coding exon and approximately 150 bp of upstream sequence was replaced by a neomycin resistance cassette. RNAse protection assays did not detect any transcripts produced from this allele in homozygous mice. (J:30057)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 77 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bmp7 Mutation:  16 strains or lines available
References
Original:  J:30057 Dudley AT, et al., A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 1995 NOV 15;9(22):2795-2807
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory