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Krastm1Mok
Targeted Allele Detail
Nomenclature
Symbol: Krastm1Mok
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Motoya Katsuki
MGI ID: MGI:1857551
Synonyms: K-ras-
Gene: Kras  Location: Chr6:145216699-145250239 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42943
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaces the 3' part of exon 1, which encodes a part of the effector domain essential for K-ras activity. (J:42943)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:  35 strains or lines available
References
Original:  J:42943 Koera K, et al., K-ras is essential for the development of the mouse embryo. Oncogene. 1997 Sep 4;15(10):1151-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory