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Targeted Allele Detail
Symbol: Prrx1tm1Jfm
Name: paired related homeobox 1; targeted mutation, James F Martin
MGI ID: MGI:1857531
Synonyms: Prx-1lacZ
Gene: Prrx1  Location: Chr1:163245119-163313710 bp, - strand  Genetic Position: Chr1, 70.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:51596
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ gene was inserted in-frame at the 5' end of the homeobox domain. A PGK- neomycin cassette was introduced 3' of the lacZ in the reverse transcriptional orientation. (J:51596)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 30 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prrx1 Mutation:  5 strains or lines available
Original:  J:51596 Lu MF, et al., prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme. Development. 1999 Feb;126(3):495-504
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory