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Targeted Allele Detail
Symbol: Tdgf1tm1Eda
Name: teratocarcinoma-derived growth factor 1; targeted mutation 1, Eileen D Adamson
MGI ID: MGI:1857518
Synonyms: Cr1-, cripto-
Gene: Tdgf1  Location: Chr9:110939608-110946158 bp, - strand  Genetic Position: Chr9, 60.79 cM
Gastrulation defects in Tdgf1tm1.1Gmin and Tdgf1tm1Eda homozygous embryos

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:51595
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo cassette replaced exons 3-5 via homologous recombination. PCR and Southern blot confirmed recombination in ES cells. These cells were used to create a second knockout. (J:47293)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 110 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tdgf1 Mutation:  58 strains or lines available
Original:  J:51595 Xu C, et al., Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development. 1999 Feb;126(3):483-94
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory