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Cd1tm1Gru
Targeted Allele Detail
Nomenclature
Symbol: Cd1tm1Gru
Name: CD1 antigen complex; targeted mutation 1, Michael Grusby
MGI ID: MGI:1857482
Synonyms: CD1-, Cd1d-, Cd1d1/Cd1d2tm1Gru, CD1d KO, CD1tm1Gru
Gene: Cd1  Location: unknown  Genetic Position: Chr3, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47769
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsBoth the Cd1d1 gene and the adjacent Cd1d2 gene were mutated in this allele. The coding sequence of Cd1d1 was replaced with a neomycin selection cassette and the coding sequence of Cd1d2 was deleted; however, the intergenic sequence was retained. Flow cytometric analysis on thymocytes derived from homozygous mice confirmed that no stable encoded protein was expressed on the cell surface. (J:47769)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Cd1 Mutation:  7 strains or lines available
References
Original:  J:47769 Smiley ST, et al., Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science. 1997 Feb 14;275(5302):977-9
All:  115 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory