Cd40^tm1Kik
Targeted Allele Detail

Summary

• Symbol: Cd40^tm1Kik
• Name: CD40 antigen; targeted mutation 1, Hitoshi Kikutani
• MGI ID: MGI:1857457
• Synonyms: CD40-, CD40 Ko, CD40KO, Tnfrsf5-, Tnfrsf5tm1Kik
• Gene: Cd40 Location: Chr2:164897535-164913574 bp, + strand Genetic Position: Chr2, 85.38 cM
• Alliance: Cd40^tm1Kik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25007
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 3. Disruption of the functionality of the protein was confirmed by a surface expression assay in spleen cells in which no binding of Tnfsf5 to ligand was observed. (J:25007)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 11 strains available Cell Lines: 0 lines available
• Carrying any Cd40 Mutation: 48 strains or lines available

References

• Original: J:25007 Kawabe T, et al., The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity. 1994 Jun;1(3):167-78
• All: 237 reference(s)