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Targeted Allele Detail
Symbol: Gria2tm1Rod
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1, John Roder
MGI ID: MGI:1857436
Synonyms: GluA2, GluR2-
Gene: Gria2  Location: Chr3:80588757-80710142 bp, - strand  Genetic Position: Chr3, 35.5 cM
Germline Transmission:  Earliest citation of germline transmission: J:64275
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced exon 11 of the gene, which encodes the pore loop and transmembrane region, TM1. Western blots of brain plasma membranes from homozygous mutant mice showed no detectable protein for the targeted gene. (J:64275)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gria2 Mutation:  49 strains or lines available
Original:  J:64275 Jia Z, et al., Enhanced LTP in mice deficient in the AMPA receptor GluR2. Neuron. 1996 Nov;17(5):945-56
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory