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Bcl2tm1Mpin
Targeted Allele Detail
Nomenclature
Symbol: Bcl2tm1Mpin
Name: B cell leukemia/lymphoma 2; targeted mutation 1, Max-Planck-Institute for Neurobiology
MGI ID: MGI:1857430
Synonyms: bcl-2 -
Gene: Bcl2  Location: Chr1:106538178-106714274 bp, - strand  Genetic Position: Chr1, 49.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34326
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsExon 2 was disrupted by the insertion of a lacZ gene and neomycin selection cassette. Western blot analysis on hippocampal lysates from homozygous mice demonstrated that no stable Bcl2 protein was made from this allele. A beta-galactosidase protein was produced from this allele under the control of the endogenous promoter. (J:34326, J:86581)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl2 Mutation:  15 strains or lines available
References
Original:  J:34326 Michaelidis TM, et al., Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron. 1996 Jul;17(1):75-89
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory