Analysis Tools
mortality/aging
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• onset of mortality ranges from 2 to 24 weeks, with a clustering at 7-8 weeks; some live substantially longer
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growth/size/body
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• weight becomes progressively smaller than wild-type, with no differences seen at P9 but not at P3
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renal/urinary system
nervous system
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• exhibit a progressive decrease in the number of superior cervical ganglia neurons, amounting to 60% of wild-type at P10 and 58% at P44
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• progressive degeneration of sympathetic neurons during early postnatal development
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• degeneration of motoneurons occurs predominately in the lateral part of the facial nucleus
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• progressive degeneration of facial motoneurons during early postnatal development, before P9
• at P9, P28, and P44, the number of facial motoneurons is only 71%, 68%, and 67%, respectively, of the number present in wild-type
• although exhibit motoneuron degeneration, motoneurons are not more vulnerable than wild-type to injury at P28
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• progressive degeneration of sensory neurons during early postnatal development
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• retinal ganglion cell loss after the period of naturally occurring cell death
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• show decreased cross-sectional area of optic nerve, reflecting a 29% loss of retinal ganglion cell axons, at P15 but not at P10, the time after the period of naturally occurring cell death
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• exhibit a progressive decrease in the number of neurons present in the third lumbar dorsal root ganglion, amounting to 90% of wild-type at P9 and 56% at P44
• subpopulation of large sensory neurons is more severely affected than the small sensory neurons
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homeostasis/metabolism
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• exhibit a 1.7-fold increase at 10 weeks of age, but not at P13
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• exhibit a 2-fold increase at 10 weeks of age, but not at P13
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vision/eye
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• retinal ganglion cell loss after the period of naturally occurring cell death
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• show decreased cross-sectional area of optic nerve, reflecting a 29% loss of retinal ganglion cell axons, at P15 but not at P10, the time after the period of naturally occurring cell death
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