About   Help   FAQ
Plautm1Mlg
Targeted Allele Detail
Nomenclature
Symbol: Plautm1Mlg
Name: plasminogen activator, urokinase; targeted mutation 1, Richard C Mulligan
MGI ID: MGI:1857289
Synonyms: u-PA-, uPA-, UPA-
Gene: Plau  Location: Chr14:20836662-20843388 bp, + strand  Genetic Position: Chr14, 11.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17427
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted using neomycin resistance cassette. The vector replaced genomic sequences encompassing all but 23 amino acids of the coding sequence. Targeting was confirmed by the absence of gene specific mRNA and immunoreactivity. (J:17427)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Plau Mutation:  5 strains or lines available
References
Original:  J:17427 Carmeliet P, et al., Physiological consequences of loss of plasminogen activator gene function in mice. Nature. 1994 Mar 31;368(6470):419-24
All:  99 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory