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Targeted Allele Detail
Symbol: Cybbtm1Din
Name: cytochrome b-245, beta polypeptide; targeted mutation 1, Mary C Dinauer
MGI ID: MGI:1857284
Synonyms: Cybb KO, Cybbtm1, Cybbtm1Din, gp91-, gp91phox, gp91phox-, gp91phox-, Nox-2-, NOX2-, PHOX-, X-CGD
Gene: Cybb  Location: ChrX:9301493-9354005 bp, - strand  Genetic Position: ChrX, 4.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:22868
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene was inserted into exon 3. Western blot analysis on extracts of neutrophil-rich peritoneal exudate cells from hemizygous male mice confirmed that no detectable protein was expressed. (J:22868)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 17 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cybb Mutation:  38 strains or lines available
Original:  J:22868 Pollock JD, et al., Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet. 1995 Feb;9(2):202-9
All:  436 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.20
The Jackson Laboratory