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Cybbtm1Din
Targeted Allele Detail
Nomenclature
Symbol: Cybbtm1Din
Name: cytochrome b-245, beta polypeptide; targeted mutation 1, Mary C Dinauer
MGI ID: MGI:1857284
Synonyms: Cybb KO, Cybbtm1, Cybbtm1Din, gp91-, gp91phox, gp91phox-, gp91phox-, Nox-2-, NOX2-, PHOX-, X-CGD
Gene: Cybb  Location: ChrX:9435252-9487771 bp, - strand  Genetic Position: ChrX, 4.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22868
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene was inserted into exon 3. Western blot analysis on extracts of neutrophil-rich peritoneal exudate cells from hemizygous male mice confirmed that no detectable protein was expressed. (J:22868)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cybb Mutation:  27 strains or lines available
References
Original:  J:22868 Pollock JD, et al., Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet. 1995 Feb;9(2):202-9
All:  338 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory