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Targeted Allele Detail
Symbol: Spntm1Bam
Name: sialophorin; targeted mutation 1, Blair Ardman
MGI ID: MGI:1857246
Synonyms: CD43-
Gene: Spn  Location: Chr7:127132232-127137823 bp, - strand  Genetic Position: Chr7, 69.35 cM, cytoband F3-F4
Germline Transmission:  Earliest citation of germline transmission: J:29272
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 300 nucleotide fragment encoding a portion of the extracellular domain and all of the transmembrane domain was deleted by via homologous recombination strategies. FACS analysis of splenocytes isolated from homozygous mutant mice showed a lack of the encoded protein on the cell surface. (J:29272)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spn Mutation:  15 strains or lines available
Original:  J:29272 Manjunath N, et al., Negative regulation of T-cell adhesion and activation by CD43. Nature. 1995 Oct 12;377(6549):535-8
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory