About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spntm1Bam
targeted mutation 1, Blair Ardman
MGI:1857246
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spntm1Bam/Spntm1Bam B6;129S4-Spntm1Bam/J MGI:3029970
hm2
 		Spntm1Bam/Spntm1Bam involves: 129S4/SvJae * C57BL/6 MGI:3029969


Genotype
MGI:3029970
hm1
Allelic
Composition		 Spntm1Bam/Spntm1Bam
Genetic
Background		 B6;129S4-Spntm1Bam/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spntm1Bam mutation (1 available); any Spn mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor incidence ( J:88253 )
• resistance to melanoma growth and metastasis in the short-term; this resistance decreases over time

immune system
immune system phenotype ( J:66401 )
N
• T cell proliferative responses are similar to controls
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:86932 )
• mice exhibited a delayed onset and reduced severity of induced experimental autoimmune encephalitis (EAE)




Genotype
MGI:3029969
hm2
Allelic
Composition		 Spntm1Bam/Spntm1Bam
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spntm1Bam mutation (1 available); any Spn mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:29272 )
N
• homozygous mice exhibit normal hematocrit, and normal leukocyte and platelet counts
• T lymphocyte development was normal; normal proportions of CD4 and CD8 subsets were present
• B cell development was normal
abnormal T cell physiology ( J:29272 )
• enhanced T cell homotypic adhesion; enhanced binding to purified ligands
increased T cell proliferation ( J:29272 , J:88252 )
• increased T cell proliferation was noted in response to various stimulation agents and natural antigens (J:29272)
• increased T cell proliferation in response to various stimulators (J:88252)

immune system
abnormal T cell physiology ( J:29272 )
• enhanced T cell homotypic adhesion; enhanced binding to purified ligands
increased T cell proliferation ( J:29272 , J:88252 )
• increased T cell proliferation was noted in response to various stimulation agents and natural antigens (J:29272)
• increased T cell proliferation in response to various stimulators (J:88252)

cellular
increased T cell proliferation ( J:29272 , J:88252 )
• increased T cell proliferation was noted in response to various stimulation agents and natural antigens (J:29272)
• increased T cell proliferation in response to various stimulators (J:88252)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory