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Targeted Allele Detail
Symbol: Juntm1Pa
Name: jun proto-oncogene; targeted mutation 1, Virginia Papaioannou
MGI ID: MGI:1857209
Synonyms: c-jun null
Gene: Jun  Location: Chr4:95049036-95052222 bp, - strand  Genetic Position: Chr4, 43.34 cM, cytoband C5-C7
Germline Transmission:  Earliest citation of germline transmission: J:13175
Parent Cell Line:  PJ5 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into the 5'-untranslated leader sequence of the gene. Southern blots of fetal tissue from homozygous mutants showed no wild-type allele present. Northern blots of embryonic fibroblasts from homozygous mutants showed no detectable mRNA for the targeted gene. (J:13175)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jun Mutation:  6 strains or lines available
Original:  J:13175 Johnson RS, et al., A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 1993 Jul;7(7B):1309-17
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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