Phenotypes associated with this allele
Allelic
Composition |
Juntm1Pa/Juntm1Pa
|
|
Genetic
Background |
either: (involves: 129S/SvEv * 129X1/SvJ) or (involves: 129X1/SvJ * C57BL/6J) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm1Pa mutation
(1 available);
any
Jun mutation
(12 available)
|
|
|
mortality/aging
|
|
• die at mid-gestation, with the majority dying between E11.5 and E13.5
|
cellular
|
|
• primary fibroblasts show greatly reduced growth rates in culture, even in the presence of various mitogens
|
cardiovascular system
|
N |
• at E10.5, embryos show normal expression of Nfatc1 (an endocardial marker) relative to controls, suggesting normal endocardial formation
• a non-significant trend toward a decrease in proliferating pHH3+ cells and an increase in apoptotic TUNEL+ cells is noted in the cardiac outflow tract (OFT) at E10.5
|
embryo
|
N |
• at E10.5, embryos show normal expression of Tfap2a during cardiac OFT development relative to controls, suggesting normal cardiac neural crest cell migration
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm1Pa mutation
(1 available);
any
Jun mutation
(12 available)
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
|
|
|
embryo
|
N |
• at E10.5, embryos show a similar pattern of Tfap2a expression in the developing cardiac outflow tract (OFT) and pharyngeal arches relative to controls, suggesting normal cardiac neural crest cell migration
|
Analysis Tools