Analysis Tools|
Allele Symbol Allele Name Allele ID |
Juntm1Pa targeted mutation 1, Virginia Papaioannou MGI:1857209 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die at mid-gestation, with the majority dying between E11.5 and E13.5
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• primary fibroblasts show greatly reduced growth rates in culture, even in the presence of various mitogens
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at E10.5, embryos show normal expression of Nfatc1 (an endocardial marker) relative to controls, suggesting normal endocardial formation
• a non-significant trend toward a decrease in proliferating pHH3+ cells and an increase in apoptotic TUNEL+ cells is noted in the cardiac outflow tract (OFT) at E10.5
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| N |
• at E10.5, embryos show normal expression of Tfap2a during cardiac OFT development relative to controls, suggesting normal cardiac neural crest cell migration
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at E10.5, embryos show a similar pattern of Tfap2a expression in the developing cardiac outflow tract (OFT) and pharyngeal arches relative to controls, suggesting normal cardiac neural crest cell migration
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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