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Cd40lgtm1Imx
Targeted Allele Detail
Nomenclature
Symbol: Cd40lgtm1Imx
Name: CD40 ligand; targeted mutation 1, Immunex
MGI ID: MGI:1857145
Synonyms: CD154-, CD40L-, CD40LKO, Tnfsf5tm1Imx
Gene: Cd40lg  Location: ChrX:57212143-57224042 bp, + strand  Genetic Position: ChrX, 31.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21137
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4 were replaced with a neomycin cassette. Homozygous mutant animals fail to express functional protein on the cell surface. (J:21137)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Cd40lg Mutation:  11 strains or lines available
References
Original:  J:21137 Renshaw BR, et al., Humoral immune responses in CD40 ligand-deficient mice. J Exp Med. 1994 Nov 1;180(5):1889-900
All:  148 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory