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Targeted Allele Detail
Symbol: Apoa1tm1Unc
Name: apolipoprotein A-I; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857127
Synonyms: A1-, Apo A1-, Apo A-1 KO, apoa1tm1unc, ApoA-I-
Gene: Apoa1  Location: Chr9:46139928-46141767 bp, + strand  Genetic Position: Chr9, 25.36 cM, cytoband A2-A4
Germline Transmission:  Earliest citation of germline transmission: J:2109
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exon 2 was replaced by a neomycin resistance cassette. The protein was not detectable in plasma by Ouchterlony double-immunodiffusion tests in homozygous mice. (J:2109)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Apoa1 Mutation:  13 strains or lines available
Original:  J:2109 Williamson R, et al., Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7134-8
All:  75 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory