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Apoa1tm1Unc
Targeted Allele Detail
Nomenclature
Symbol: Apoa1tm1Unc
Name: apolipoprotein A-I; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857127
Synonyms: A1-, Apo A1-, Apo A-1 KO, apoa1tm1unc, ApoA-I-
Gene: Apoa1  Location: Chr9:46228580-46230466 bp, + strand  Genetic Position: Chr9, 25.36 cM, cytoband A2-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:2109
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing exon 2 was replaced by a neomycin resistance cassette. The protein was not detectable in plasma by Ouchterlony double-immunodiffusion tests in homozygous mice. (J:2109)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apoa1 Mutation:  2 strains or lines available
References
Original:  J:2109 Williamson R, et al., Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7134-8
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory