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Agttm2Unc
Targeted Allele Detail
Nomenclature
Symbol: Agttm2Unc
Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8); targeted mutation 2, University of North Carolina
MGI ID: MGI:1857122
Synonyms: AgtTgH(Agtdup)1Unc, Tg(Agtdup)1Unc, TgH(Agtdup)1Unc
Gene: Agt  Location: Chr8:125283326-125296445 bp, - strand  Genetic Position: Chr8, 72.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:18272
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Duplication
  Agttm2Unc involves 1 genes/genome features (Agt) View all
 
Mutation detailsA tandem duplication of the gene was created by "gap-repair" gene targeting. Radioimmunoassay tests demonstrated increased plasma levels of the encoded protein in heterozygous mice. (J:18272)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agt Mutation:  23 strains or lines available
Notes
Human AGT and renin genes can complement the effects of the mouse null mutation (J:39934).
References
Original:  J:18272 Smithies O, et al., Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3612-5
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory