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MipCat-Lop
Spontaneous Allele Detail
Nomenclature
Symbol: MipCat-Lop
Name: major intrinsic protein of lens fiber; cataract lens opacity
MGI ID: MGI:1857105
Gene: Mip  Location: Chr10:128225838-128231812 bp, + strand  Genetic Position: Chr10, 76.49 cM, cytoband D1
Mutation
origin
Strain of Origin:  STOCK Rb(6.15)1Ald
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA G to C transversion at position 151 of the encoded mRNA results in a non-conservative change at amino acid 51 from alanine to proline. This mutation inhibits targeting of the mutant product to the cell membrane. (J:31574)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mip Mutation:  24 strains or lines available
References
Original:  J:6702 Lyon MF, et al., Lens opacity: a new gene for congenital cataract on chromosome 10 of the mouse. Genet Res. 1981 Dec;38(3):337-41
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory