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Spontaneous Allele Detail
Symbol: MipCat-Fr
Name: major intrinsic protein of lens fiber; dominant cataract Fraser
MGI ID: MGI:1857104
Synonyms: Cat60, shrivelled, Svl
Gene: Mip  Location: Chr10:128225838-128231812 bp, + strand  Genetic Position: Chr10, 76.49 cM, cytoband D1
Strain of Origin:  A/J
Allele Type:    Spontaneous
Mutation:    Transposon insertion
Mutation detailsA transposon-induced error in splicing introduces a long terminal repeat sequence replacing the normal carboxy terminus in mutant mice. (J:5045, J:31574)
Inheritance:    Semidominant
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mip Mutation:  19 strains or lines available
In chimeric embryos formed between a strain of mice homozygous for MipCat-Fr and the DBA/2 strain, homozygous for the wild-type Mip allele, the lens is histologically, cellularly, and biochemically normal (J:35863). A study of the lens crystallins shows a decrease in the proportion of a-crystallins and an increase in the proportion of a-crystallins (J:6987). At birth, a-crystallin mRNAs are present in nearly normal amounts and functional capacity but are selectively lost by 40 days of age. The effect is more severe in homozygotes than in heterozygotes. The a-crystallin cellular DNA does not differ from normal (J:7668).

Original:  J:206638 Fraser FC, et al., 'Shrivelled', a hereditary degeneration of the lens in the house mouse. Genet Res. 1962;3(3):383-387
All:  13 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory