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Gpr161vl
Spontaneous Allele Detail
Nomenclature
Symbol: Gpr161vl
Name: G protein-coupled receptor 161; vacuolated lens
MGI ID: MGI:1857087
Gene: Gpr161  Location: Chr1:165295789-165326745 bp, + strand  Genetic Position: Chr1, 72.64 cM
Gpr161vl/Gpr161vl

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C3HeB/FeJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsThe molecular lesion is an 8-bp deletion in exon 4. This mutation is expected to cause a frameshift and premature stop codon 50 nt 3' of the deletion that results in the incorporation of 16 novel amino acids (GAHGRRTVPGTQQQHR) and truncation of the GPCR at residue 386, deleting 143 (of 203) amino acids of the C-terminal tail. An in vitro assay showed that a smaller protein can be expressed from a construct carrying this mutation and assay results suggest that internalization of the protein from the plasma membrane into the endosomal compartment is disrupted by this mutation. (J:131929)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpr161 Mutation:  16 strains or lines available
References
Original:  J:13464 Dickie MM, Vacuolated lens. Mouse News Lett. 1967;36:39-40
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory