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Mregdsu
Spontaneous Allele Detail
Nomenclature
Symbol: Mregdsu
Name: melanoregulin; dilute suppressor
MGI ID: MGI:1856847
Synonyms: dsu
Gene: Mreg  Location: Chr1:72159442-72212307 bp, - strand  Genetic Position: Chr1, 36.39 cM
Myo5ad/ Myo5ad and Myo5ad/ Myo5ad Mregdsu/ Mregdsu

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  STOCK a Myo5ad cw
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsGenomic PCR and DNA sequencing analysis showed the mutation is a deletion that spans the region from 11.1-kb upstream of the initiator methionine to intron 2. Northern and RT-PCR analysis demonstrated that no wild-type transcript could be detected in the mutant animals. Western blot analysis of homozygous mutant melanocytes showed that it also is not expressed at the protein level. (J:94728)
Inheritance:    Semidominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mreg Mutation:  94 strains or lines available
References
Original:  J:7171 Sweet HO, Dilute suppressor, a new suppressor gene in the house mouse. J Hered. 1983 Jul-Aug;74(4):305-6
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory