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Targeted Allele Detail
Symbol: Abl1m1
Name: c-abl oncogene 1, non-receptor tyrosine kinase; Abelson leukemia oncogene m1
MGI ID: MGI:1856663
Synonyms: ablm1
Gene: Abl1  Location: Chr2:31578388-31694239 bp, + strand  Genetic Position: Chr2, 21.86 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:72519
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA promoterless neomycin resistance gene was inserted into coding sequences corresponding to the carboxy terminus of the protein, downstream of the tyrosine kinase domain and nuclear targeting sequences. This allele expresses a protein with a functional kinase domain but a disrupted carboxy terminus containing the DNA and actin binding domains. (J:72518)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abl1 Mutation:  80 strains or lines available
Original:  J:72519 Schwartzberg PL, et al., Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science. 1989 Nov 10;246(4931):799-803
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory