|
Allele Symbol Allele Name Allele ID |
Abl1m1 mutation 1 MGI:1856663 |
||||||||||||||||||||||||
| Summary |
5 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• animals surviving to weaning are highly susceptible to infection
• only about 15% survive to 6 weeks of age
|
|
• homozygous growth and development grossly normal through E17
• 75% of pups die within the first week after birth
|
|
• young pups weigh 30-80% as much as controls
• low body weight persists through life
|
|
• mature B cell population in bone marrow seems unaffected
• mature B cell numbers in peripheral blood and lymph nodes are normal
|
|
• depleted by half to 2/3
|
|
• severely reduced in number
|
|
• depleted by half to 2/3 1n bone marrow
• depletion less severe in the spleen
• pre-B cell numbers normal in newborn spleen but become reduced over time
|
|
• somewhat reduced CD4+ and CD8+ cells in peripheral blood
|
|
• elevated CD4+ and CD8+ cells in the spleen
|
|
• involuted thymi frequently found in mice dead at weaning
|
|
• in mice dead at weaning
|
|
• small thymus in many newborns
• 1/3 as many cells as in controls
|
|
• early thymocyte numbers are sometimes reduced
|
|
• round kidney shaped spleens
|
|
• cell numbers in new born spleens about 50% of controls
|
|
• white pulp depleted in mice showing extreme B cell depletion
|
|
• animals surviving to weaning are highly susceptible to infection
|
|
• slight shortening of the skull
|
|
• many born with eyes open
• eyes often become damaged
|
|
• involuted thymi frequently found in mice dead at weaning
|
|
• in mice dead at weaning
|
|
• small thymus in many newborns
• 1/3 as many cells as in controls
|
|
• early thymocyte numbers are sometimes reduced
|
|
• mature B cell population in bone marrow seems unaffected
• mature B cell numbers in peripheral blood and lymph nodes are normal
|
|
• depleted by half to 2/3
|
|
• severely reduced in number
|
|
• depleted by half to 2/3 1n bone marrow
• depletion less severe in the spleen
• pre-B cell numbers normal in newborn spleen but become reduced over time
|
|
• somewhat reduced CD4+ and CD8+ cells in peripheral blood
|
|
• elevated CD4+ and CD8+ cells in the spleen
|
|
• round kidney shaped spleens
|
|
• cell numbers in new born spleens about 50% of controls
|
|
• white pulp depleted in mice showing extreme B cell depletion
|
|
• slight shortening of the skull
|
|
• involuted thymi frequently found in mice dead at weaning
|
|
• in mice dead at weaning
|
|
• small thymus in many newborns
• 1/3 as many cells as in controls
|
|
• early thymocyte numbers are sometimes reduced
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• spleen cell response to lipopolysaccharides is about 10% that of controls, correcting for reduced B cell numbers
• reduced spleen response to anti-IgM
|
|
• response of peripheral blood cells to lipopolysaccharide is about 38% of control response
• response of peripheral blood cells to "conA" is reduced to about 18% of control response
|
|
• severe depletion becomes more common in mutants over 10 weeks of age
|
|
• CD43+,B220+ pro-B cells are reduced by 55% in bone marrow at 2 months of age
• 77% of control levels overall
|
|
• B220+,IgM+ B cells reduced to about 46% of controls in bone marrow at 2 months of age
• levels reduced overall to 67% of controls
|
|
• almost completely depleted in bone marrow at 2 months of age
• overall levels at 63% of controls
|
|
• severe depletion becomes more common in mutants over 10 weeks of age
|
|
• CD43+,B220+ pro-B cells are reduced by 55% in bone marrow at 2 months of age
• 77% of control levels overall
|
|
• B220+,IgM+ B cells reduced to about 46% of controls in bone marrow at 2 months of age
• levels reduced overall to 67% of controls
|
|
• almost completely depleted in bone marrow at 2 months of age
• overall levels at 63% of controls
|
|
• bone marrow cell response to Il7 is elevated in young animals and reduced in older ones
|
|
• spleen cell response to lipopolysaccharides is about 10% that of controls, correcting for reduced B cell numbers
• reduced spleen response to anti-IgM
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• common lymphoid progenitors are dramatically reduced in number
|
|
• "fraction A" pro-B-cells are dramatically reduced in number
|
|
• calcium flux response to CD19 cross linking is absent
|
|
• common lymphoid progenitors are dramatically reduced in number
|
|
• "fraction A" pro-B-cells are dramatically reduced in number
|
|
• calcium flux response to CD19 cross linking is absent
|
|
• bone marrow cell response to Il7 is elevated
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools