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Otogtwt
Spontaneous Allele Detail
Nomenclature
Symbol: Otogtwt
Name: otogelin; twister
MGI ID: MGI:1856640
Synonyms: twt
Gene: Otog  Location: Chr7:46240987-46311434 bp, + strand  Genetic Position: Chr7, 29.66 cM, cytoband B4-C
Cochlea and vestibule comparisons of Otogtwt/Otogtwt and wild-type mice.

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  B6C3Fe a/a-Large1myd/+
Mutation
description
Allele Type:    Spontaneous
Mutation:    Other
 
Mutation detailsComplementation studies established that twister is an allele of Otog. Southern blot analysis of the mutant gene suggested that a point mutation or a small discrete rearrangement in the 3' region that created a new BstEII site was responsible for the mutant phenotype. (J:65390)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otog Mutation:  5 strains or lines available
References
Original:  J:13873 Lane PW, Twister (twt). Mouse News Lett. 1981;64:59
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory