Phenotypes associated with this allele

• Allele Symbol: Otog^twt
• Allele Name: twister
• Allele ID: MGI:1856640
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otog^twt/Otog^twt	involves: C3HeB/Fe * C57BL/6	MGI:3714960

Genotype
MGI:3714960

hm1

• Allelic Composition: Otog^twt/Otog^twt
• Genetic Background: involves: C3HeB/Fe * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cochlea and vestibule comparisons of Otog^twt/Otog^twt and wild-type mice.

behavior/neurological

abnormal pinna reflex ( J:65390 )

• Preyer reflex is normal at 3-4 weeks of age but by 10-20 weeks of age, a weak Preyer reflex is seen in 5 of 7 mutants

impaired righting response ( J:65390 )

• mutants at P4 tend to stay on their back when placed upside down

• mutants show an abnormal response in the air righting reflex and in the contact righting reflex tests

absent startle reflex ( J:65390 )

• none of the mutants at 10-20 weeks of age exhibit a body startle reflex

abnormal placing response ( J:65390 )

• as early as P4, mutants exhibit head and trunk curling when picked up by their tail

impaired balance ( J:65390 )

• the abnormal placing response, righting response, and response in the elevated platform test appear to result from impaired balance

impaired coordination ( J:65390 )

• show an abnormal response in the elevated platform test

head tilt ( J:65390 )

• after 2 weeks of age, most mutants have a tilted head on one side

• all mutants adopt a swimming, circling style with tilted head but do not sink

hyperactivity ( J:65390 )

• some mutants show hyperactivity

circling ( J:65390 )

• some mutants exhibit circling behavior

• all mutants adopt a swimming, circling style with tilted head but do not sink

hearing/vestibular/ear

abnormal crista ampullaris morphology ( J:65390 )

• in the cristae ampullares, the cupulae are detached in older (P170) mutants

abnormal otolithic membrane morphology ( J:65390 )

• in the saccule, the octoconial membrane is slightly displaced but is still partially attached to the sensory epithelium

detached otolithic membrane ( J:65390 )

• the otoconial membrane is present but fully detached in the utricle

abnormal ear physiology ( J:65390 )

increased or absent threshold for auditory brainstem response ( J:65390 )

• the threshold sound pressure levels required for detection of an ABR are elevated in mutants both for a click stimulus an for all pure tone tested; the decrease in hearing sensitivity for a click stimulus averages 50 dB

impaired hearing ( J:65390 )

• moderate to severe/profound hearing loss as indicated by the click- and pure one-evoked auditory brainstem response

reproductive system

reduced fertility ( J:65390 )

• mutants are poor breeders