Mip^Hfi
Radiation induced Allele Detail

Summary

• Symbol: Mip^Hfi
• Name: major intrinsic protein of lens fiber; hydropic fibers
• MGI ID: MGI:1856608
• Synonyms: 538
• Gene: Mip Location: Chr10:128061707-128067681 bp, + strand Genetic Position: Chr10, 76.49 cM, cytoband D1
• Alliance: Mip^Hfi page

Mutation origin

• Strain of Origin: (101 x C3H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intragenic deletion
• Mutation details: A 76 bp deletion that removes 17 bp from the 3' end of exon 2 and 59 bp of intron 2. In the encoded mRNA, 165 bp of coding sequence is removed resulting from exon 2 being skipped during the splicing process. By immunoblot analysis on lens cell memebrane preparations, a smaller mutant protein was detected in homozygous mutant mice, although at lower levels that the wild-type protein. (J:70225)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mip Mutation: 31 strains or lines available

References

• Original: J:14285 Kratochvilova J, Allelism tests of 15 autosomal cataract mutations. Mouse Genome. 1990;86:249-50
• All: 4 reference(s)