a^18H
Chemically and radiation induced Allele Detail

Summary

• Symbol: a^18H
• Name: nonagouti; 18 Harwell
• MGI ID: MGI:1856404
• Synonyms: Itch^-, itchy
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: a^18H page

Mutation origin

• Strain of Origin: C3H/HeH

Mutation description

• Allele Type: Chemically and radiation induced
• Mutation: Inversion
• a^18H involves 1 genes/genome features (Itch) View all
• Mutation details: This mutation comprises a paracentric inversion with deletions of 20 and 18 bp from the proximal and distal breakpoints, respectively. A probe from the agouti locus that differentiates polymorphisms between C3H/HeH and 101/H was used to show that the mutation arose on C3H/HeH. The mutating event affected the regulation of agouti, down regulating the expression of pheomelanin. The distal breakpoint is in the intron between exons 1 and 2 of the Itch gene and is responsible for an immunological defect. (J:24934, J:45910)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any a Mutation: 463 strains or lines available

References

• Original: J:163587 Cattanach BM, et al., Agouti locus mutations at Harwell. Mouse News Lett. 1987;77:123-125
• All: 27 reference(s)