Dct^Slt-lt
Spontaneous Allele Detail

Summary

• Symbol: Dct^Slt-lt
• Name: dopachrome tautomerase; slaty light
• MGI ID: MGI:1856381
• Gene: Dct Location: Chr14:118250202-118289656 bp, - strand Genetic Position: Chr14, 61.6 cM
• Alliance: Dct^Slt-lt page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The mutation has been identified as an G-to-A transition (C-to-T on forward strand) at coding nucleotide position 1456 in exon 8, that results in replacement of glycine with arginine at amino acid position 486 (p.G486R), in the predicted transmembrane domain of the protein. The mutation does not prevent membrane insertion, but it shifts the entire transmembrane region approximately four amino acids toward the N-terminus. (J:28826, J:117576)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dct Mutation: 35 strains or lines available

References

• Original: J:27515 Cook S, et al., Remutation to slaty. Mouse Genome. 1994;92:672
• All: 4 reference(s)