About   Help   FAQ
Spontaneous Allele Detail
Symbol: ArTfm
Name: androgen receptor; testicular feminization
MGI ID: MGI:1856319
Synonyms: Tfm
Gene: Ar  Location: ChrX:98149721-98323215 bp, + strand  Genetic Position: ChrX, 42.82 cM
Strain of Origin:  (STOCK EdaTa x Atp7aMo-blo)F1
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
Mutation detailsA frameshift mutation resulting from the deletion of a single cytosine residue generated a premature stop codon at residue 412. The nonsense mutation is expected to preclude the translation of both the DNA- and steroid-binding domains. (J:712, J:1264, J:11219, J:19598, J:30797)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 266 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ar Mutation:  17 strains or lines available
ArTfm acts by causing insensitivity to androgens due to a defect in androgen-binding receptor present in cytosol and nucleus. Most responses to androgens are absent or defective in ArTfm/Y males and are not inducible by administration of androgens (J:5221, J:5532). Androgen receptor is found in kidney, submandibular gland (J:5667) and brain (J:5927). ArTfm/Y males have about 20-25 percent of normal testosterone-binding activity in brain (J:6096) and 10-20 percent in kidney.
Original:  J:30664 Lyon MF, Testicular feminization, proposed symbol Tfm. Mouse News Lett. 1969;41:28
All:  72 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory