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ArTfm
Spontaneous Allele Detail
Nomenclature
Symbol: ArTfm
Name: androgen receptor; testicular feminization
MGI ID: MGI:1856319
Synonyms: Tfm
Gene: Ar  Location: ChrX:98149721-98323215 bp, + strand  Genetic Position: ChrX, 42.82 cM
Mutation
origin
Strain of Origin:  (STOCK EdaTa x Atp7aMo-blo)F1
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation details
Inheritance:    Dominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 263 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ar Mutation:  20 strains or lines available
Notes
ArTfm acts by causing insensitivity to androgens due to a defect in androgen-binding receptor present in cytosol and nucleus. Most responses to androgens are absent or defective in ArTfm/Y males and are not inducible by administration of androgens (J:5221, J:5532). Androgen receptor is found in kidney, submandibular gland (J:5667) and brain (J:5927). ArTfm/Y males have about 20-25 percent of normal testosterone-binding activity in brain (J:6096) and 10-20 percent in kidney.

References
Original:  J:30664 Lyon MF, Testicular feminization, proposed symbol Tfm. Mouse News Lett. 1969;41:28
All:  67 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory