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Spontaneous Allele Detail
Symbol: KitW-sh
Name: KIT proto-oncogene receptor tyrosine kinase; sash
MGI ID: MGI:1856265
Synonyms: c-Kitwsh, Sash, Wsh, Wsh, W-sh
Gene: Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: KitW-sh page
Strain of Origin:  (C3H/HeH x 101/H)F1
Allele Type:    Spontaneous
Mutation:    Inversion
  KitW-sh involves 32 genes/genome features (Tec, Slain2, Slc10a4 ...) View all
Mutation detailsThe molecular mutation of this allele is an inversion located proximal to the Kit structural gene that disrupts 5' regulatory sequences. Transcripts were not detectable from this allele in cultured mast cells derived from homozygous mice. However, an analysis of embryonic expression revealed that ectopic expression of Kit occurred in homozygous mice and normal expression was ablated. (J:2535, J:6857, J:13166, J:25082, J:29686)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 93 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 11 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  148 strains or lines available
Original:  J:6857 Lyon MF, et al., A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice. Genet Res. 1982 Jun;39(3):315-22
All:  311 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory