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Spontaneous Allele Detail
Symbol: MitfMi-wh
Name: microphthalmia-associated transcription factor; white
MGI ID: MGI:1856088
Synonyms: mitfwh, Miwh
Gene: Mitf  Location: Chr6:97807058-98021349 bp, + strand  Genetic Position: Chr6, 45.05 cM
MitfMi-wh/+ and MitfMi-wh/MitfMi-wh and control

Show the 4 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL x DBA)F1
Allele Type:    Spontaneous
Mutation:    Single point mutation
Mutation detailsT to A transversion at bp 764, which leads to an isoleucine to asparagine substitution at the corresponding amino acid (212) in the encoded protein. This mutation is in the basic region of the protein. (J:19656, J:21366)
Inheritance:    Semidominant
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 11 strains available      Cell Lines: 0 lines available
Carrying any Mitf Mutation:  44 strains or lines available
Combination heterozygotes of MitfMi-wh/MitfMi, MitfMi-wh/MitfMi-b, and MitfMi-wh/MitfMi-ws show some interallelic complementation in that the heterozygote of the two alleles is more nearly normal than either homozygote (J:12967, J:19656). MitfMi-b/MitfMi-wh agouti mice are light cream with white spots and ruby eyes (J:15061).

Original:  J:13058 Grobman AB, et al., Mutant white mice. A new dominant autosomal mutant affecting coat color in Mus musculus. J Hered. 1947;38:381-384
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory