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Mgrn1md
Spontaneous Allele Detail
Nomenclature
Symbol: Mgrn1md
Name: mahogunin, ring finger 1; mahoganoid
MGI ID: MGI:1856070
Synonyms: md
Gene: Mgrn1  Location: Chr16:4704113-4756160 bp, + strand  Genetic Position: Chr16, 2.48 cM, cytoband A1
Mgrn1md/+ and Mgrn1md/Mgrn1md

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C3H/HeJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Transposon insertion
 
Mutation detailsThe mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice. (J:80182)
Inheritance:    Recessive
Schematic of the location of the IAP insertion generating the Mgrn1md allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Mgrn1 Mutation:  51 strains or lines available
Notes
The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrnmg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791).
References
Original:  J:13379 Lane PW, mahoganoid, md. Mouse News Lett. 1960;22:35
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory