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Hrrh
Spontaneous Allele Detail
Nomenclature
Symbol: Hrrh
Name: hairless; rhino
MGI ID: MGI:1856059
Gene: Hr  Location: Chr14:70552212-70573548 bp, + strand  Genetic Position: Chr14, 36.32 cM
Hrrh/Hrrh

Show the 1 image(s) involving this allele.

Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Spontaneous
Mutation:    Undefined
    This allele is defined by a noncomplementation test with Hrhr.
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hr Mutation:  30 strains or lines available
Notes
Rhino mice represent a genetic disorder affecting the meibomian gland structure and function. Ductal epithelial hyperkeratinization leads to plugging of the gland orifice and gland atrophy. Hyperkeratinization was not seen in the conjunctival or corneal epithelium (J:16021). Rhino mice have spleen cells with a defective response to T-dependent antigens (J:6391) and they develop an autoimmune disease characterized by hypergammaglobulinemia, immunoglobulin deposits in basement membrane of skin, spleen, liver, and kidney, and presence of antinuclear antibodies which appear in young mice and increase with age (J:6387).

References
Original:  J:13057 Howard A, "Rhino," an allele of hairless in the house mouse. J Hered. 1940;31:467-470
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory