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Spontaneous Allele Detail
Symbol: Hrrh
Name: hairless; rhino
MGI ID: MGI:1856059
Gene: Hr  Location: Chr14:70552212-70573548 bp, + strand  Genetic Position: Chr14, 36.32 cM

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  Not Specified
Allele Type:    Spontaneous (Not Specified)
Mutation:    Undefined
    This allele is defined by a noncomplementation test with Hrhr.
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hr Mutation:  44 strains or lines available
Rhino mice represent a genetic disorder affecting the meibomian gland structure and function. Ductal epithelial hyperkeratinization leads to plugging of the gland orifice and gland atrophy. Hyperkeratinization was not seen in the conjunctival or corneal epithelium (J:16021). Rhino mice have spleen cells with a defective response to T-dependent antigens (J:6391) and they develop an autoimmune disease characterized by hypergammaglobulinemia, immunoglobulin deposits in basement membrane of skin, spleen, liver, and kidney, and presence of antinuclear antibodies which appear in young mice and increase with age (J:6387).

Original:  J:13057 Howard A, "Rhino," an allele of hairless in the house mouse. J Hered. 1940;31:467-470
All:  19 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory