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Leprdb-Pas
Spontaneous Allele Detail
Nomenclature
Symbol: Leprdb-Pas
Name: leptin receptor; diabetes Institut Pasteur
MGI ID: MGI:1856013
Synonyms: dbPas, diabetes-Pasteur, obese-like
Gene: Lepr  Location: Chr4:101717404-101815352 bp, + strand  Genetic Position: Chr4, 46.96 cM
Mutation
origin
Strain of Origin:  DW/Pas
Mutation
description
Allele Type:    Spontaneous
Mutation:    Duplication
  Leprdb-Pas involves 1 genes/genome features (Lepr) View all
 
Mutation detailsSouthern analysis indicates that the mutation in the Pas allele is a partial duplication of the coding sequence for the putative extracellular domain of the protein. (J:31419, J:49607)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  76 strains or lines available
References
Original:  J:31095 Guenet JL, A mutation in the DW inbred line producting an obese phenotype. Mouse News Lett. 1982;67:30
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory