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Tyrc-e
Spontaneous Allele Detail
Summary
Symbol: Tyrc-e
Name: tyrosinase; extreme dilution
MGI ID: MGI:1855978
Synonyms: cd, ce
Gene: Tyr  Location: Chr7:87073979-87142720 bp, - strand  Genetic Position: Chr7, 49.01 cM
Alliance: Tyrc-e page
Mutation
origin
Strain of Origin:  wild
Mutation
description
Allele Type:    Spontaneous
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:  360 strains or lines available
Notes
Tyrc-e, extreme dilution. This mutation was found in the wild by Detlefsen (J:34484). Hair is very light gray, and eyes are black. Melanin granules of both retinal and neural-crest derived melanocytes are pigmented but are smaller and fewer than normal (J:12970, J:5001). Tyrosinase activity in the skin is very low (J:30744). Tyrc-e/Tyrc mice are almost white with black eyes.
References
Original:  J:34484 Detlefsen JA, A new mutation in the house mouse. Am Naturalist. 1921 Sep-Oct;55:469-73
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory