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Tyrp1b
Spontaneous Allele Detail
Nomenclature
Symbol: Tyrp1b
Name: tyrosinase-related protein 1; brown
MGI ID: MGI:1855960
Synonyms: b
Gene: Tyrp1  Location: Chr4:80834123-80851719 bp, + strand  Genetic Position: Chr4, 37.89 cM
a/a Tyrp1b/Tyrp1b

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  old mutant of the mouse fancy
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation changes cysteine to tyrosine at position 110 (p.C110Y) in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. (J:44435)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 79 strains available      Cell Lines: 0 lines available
Carrying any Tyrp1 Mutation:  132 strains or lines available
References
Original:  J:30758 Gruneberg H, in The Genetics of the Mouse. 1952
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory