About   Help   FAQ
Spontaneous Allele Detail
Symbol: Avy
Name: nonagouti; agouti viable yellow
MGI ID: MGI:1855930
Gene: a  Location: Chr2:154791402-155051012 bp, + strand  Genetic Position: Chr2, 76.83 cM
Spectrum of coat colors in Avy/a mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C3H/HeJ
Allele Type:    Spontaneous
Mutation:    Transposon insertion
Mutation detailsAn intracisternal A particle (IAP) retrotransposon is inserted 100kb upstream of agouti coding sequences causing ectopic, allele-specific imprinting of agouti protein expression. (J:19977, J:21244, J:79708)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any a Mutation:  451 strains or lines available
The Avy allele arose spontaneously in the C3H/HeJ strain. Avy resembles Ay except that homozygotes are viable and resemble heterozygotes with lower members of the series. Both homozygotes (Avy/Avy) and heterozygotes (Avy/A and Avy/a) show considerable variation in appearance, ranging from clear yellow, through mottling with dark patches, to a completely agouti-like coat (J:5475). The variation is strongly influenced by the agouti-locus genotype and strain genome of the dam (J:6103). A larger proportion of homozygotes than heterozygotes are clear yellow (J:13080). In combination with the dominant spotting allele KitW-2J, Avy heterozygotes that have the agouti phenotype have much larger white spots than those of yellow or mottled yellow phenotype (J:12035). Homozygotes and heterozygotes tend to become obese, and the degree of obesity is correlated with the amount of yellow in the coat (J:13142), except that Eso prevents synthesis of yellow pigment in Avy/- mice but does not prevent obesity (J:6103). Avy resembles a in causing greater tumor susceptibility and lower graft vs. host reactivity (J:5320) and higher hepatic malic enzyme activity (J:5759). The greater tumor susceptibility as well as several altered immune responses occur in Avy/a mice of mottled phenotype but not in those of agouti phenotype (J:7421).

Genbank ID for this mutation: S74479

Original:  J:13080 DICKIES MM, A new viable yellow mutation in the house mouse. J Hered. 1962 Mar-Apr;53:84-6
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory