Hat1tm1.1Mrpa
Targeted Allele Detail
|
|
| Symbol: |
Hat1tm1.1Mrpa |
| Name: |
histone aminotransferase 1; targeted mutation 1.1, Mark R Parthun |
| MGI ID: |
MGI:5523519 |
| Synonyms: |
Hat1-, Hat1delta3 |
| Gene: |
Hat1 Location: Chr2:71219604-71271966 bp, + strand Genetic Position: Chr2, 42.38 cM
|
| Alliance: |
Hat1tm1.1Mrpa page
|
|
Skeletal defects in Hat1tm1.1Mrpa/Hat1tm1.1Mrpa mice
Show the 2 phenotype image(s) involving this allele.
|
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:199077
|
| Parent Cell Line: |
Bruce 4 (ES Cell)
|
| Strain of Origin: |
B6.Cg-Thy1a
|
|
| Allele Type: |
|
Targeted (Null/knockout) |
| Mutations: |
|
Insertion, Intragenic deletion
|
| |
|
Mutation details: A loxP site was inserted upstream of exon 3. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the neomycin resistance cassette. The predicted product of this allele lacks the entire active site. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts.
(J:199077)
|
|
Generation of the Hat1tm1Mrpa and Hat1tm1.1Mrpa alleles |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Hat1 Mutation: |
42 strains or lines available
|
|
| Original: |
J:199077 Nagarajan P, et al., Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. PLoS Genet. 2013 Jun;9(6):e1003518 |
| All: |
2 reference(s) |
|
Analysis Tools
