Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Klbtm1.1Akha
Name:	klotho beta; targeted mutation 1.1, Alexei Kharitonenkov
MGI ID:	MGI:5494481
Gene:	Klb  Location: Chr5:65505657-65541350 bp, + strand  Genetic Position: Chr5, 33.64 cM
Alliance:	Klbtm1.1Akha page

Germline Transmission:	Earliest citation of germline transmission: J:195570
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Flp-mediated recombination removed exons 1 through 4. Western blot analysis confirmed the absence of protein in the liver and white adipose tissue. (J:195570)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klb Mutation:	58 strains or lines available

Original:	J:195570 Adams AC, et al., FGF21 requires betaklotho to act in vivo. PLoS One. 2012;7(11):e49977
All:	1 reference(s)