Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Sppl2atm1Basc Name: signal peptide peptidase like 2A; targeted mutation 1, Bernd Schroder MGI ID: MGI:5491887 Gene: Sppl2a  Location: Chr2:126732311-126775155 bp, - strand  Genetic Position: Chr2, 61.76 cM, cytoband F3 Alliance: Sppl2atm1Basc page

Atrophic Peyer's patches in Sppl2atm1Basc/Sppl2atm1Basc mice Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:194664
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 2. Western confirmed the lack of protein expression in splenocytes. (J:194664)

Generation of the Sppl2atm1Basc allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sppl2a Mutation:	45 strains or lines available

Original:	J:194664 Schneppenheim J, et al., The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain. J Exp Med. 2013 Jan 14;210(1):41-58
All:	7 reference(s)