Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sppl2atm1Dgen
Name:	signal peptide peptidase like 2A; targeted mutation 1, Deltagen
MGI ID:	MGI:5484576
Gene:	Sppl2a  Location: Chr2:126732311-126775155 bp, - strand  Genetic Position: Chr2, 61.76 cM, cytoband F3
Alliance:	Sppl2atm1Dgen page

Germline Transmission:	Earliest citation of germline transmission: J:194595
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout) Mutation:    Not Specified     No details provided. (J:194595)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sppl2a Mutation:	45 strains or lines available

Original:	J:194595 Beisner DR, et al., The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain. J Exp Med. 2013 Jan 14;210(1):23-30
All:	1 reference(s)