Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Supv3l1tm1Whle
Name:	suppressor of var1, 3-like 1 (S. cerevisiae); targeted mutation 1, Wen-Hwa Lee
MGI ID:	MGI:5469429
Synonyms:	mSuv3-
Gene:	Supv3l1  Location: Chr10:62264988-62285517 bp, - strand  Genetic Position: Chr10, 32.4 cM
Alliance:	Supv3l1tm1Whle page

Germline Transmission:	Earliest citation of germline transmission: J:193361
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neo cassette was inserted into the location corresponding to the human codon 684. This renders the mRNA unstable. (J:193361)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Supv3l1tm1Whle

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Supv3l1 Mutation:	42 strains or lines available

Original:	J:193361 Chen PL, et al., Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Oncogene. 2013 Feb 28;32(9):1193-201
All:	1 reference(s)