Phenotypes associated with this allele

• Allele Symbol: Supv3l1^tm1Whle
• Allele Name: targeted mutation 1, Wen-Hwa Lee
• Allele ID: MGI:5469429
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Supv3l1^tm1Whle/Supv3l1^tm1Whle	involves: 129P2/OlaHsd * C57BL/6	MGI:5469448
ht2	Supv3l1^tm1Whle/Supv3l1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5469451

Genotype
MGI:5469448

hm1

• Allelic Composition: Supv3l1^tm1Whle/Supv3l1^tm1Whle
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:193361 )

• mice start to degenerate by E8.5 and die by E9.5

embryonic lethality between implantation and placentation, incomplete penetrance ( J:193361 )

• mice start to degenerate by E8.5 and die by E9.5

embryo

embryonic growth retardation ( J:193361 )

• at E7.5 to E8.0

decreased embryo size ( J:193361 )

absent egg cylinders ( J:193361 )

growth/size/body

embryonic growth retardation ( J:193361 )

• at E7.5 to E8.0

decreased embryo size ( J:193361 )

Genotype
MGI:5469451

ht2

• Allelic Composition: Supv3l1^tm1Whle/Supv3l1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cellular

maternal effect ( J:193361 )

• subsequent crosses to C57BL/6 leads to mitochondrial genome instability, reduced mitochondrial DNA copy number, impaired mitochondrial proliferation capability, higher tumor incidence (lymphoma and carcinoma) and shortened lifespan regardless of offspring genotype