Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pla2g5tm1.1Kiku
Name:	phospholipase A2, group V; targeted mutation 1.1, Kiyotaka Kugiyama
MGI ID:	MGI:5431474
Gene:	Pla2g5  Location: Chr4:138526558-138590780 bp, - strand  Genetic Position: Chr4, 70.57 cM
Alliance:	Pla2g5tm1.1Kiku page

Germline Transmission:	Earliest citation of germline transmission: J:186024
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Cre-mediated recombination removed exon 4 and the neo cassette. RT-PCR confirmed the absence of transcript expression in the heart. (J:186024)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pla2g5 Mutation:	21 strains or lines available

Original:	J:186024 Yano T, et al., Group V secretory phospholipase A2 plays a pathogenic role in myocardial ischaemia-reperfusion injury. Cardiovasc Res. 2011 May 1;90(2):335-43
All:	2 reference(s)