Phenotypes associated with this allele

• Allele Symbol: Pla2g5^tm1.1Kiku
• Allele Name: targeted mutation 1.1, Kiyotaka Kugiyama
• Allele ID: MGI:5431474
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2g5^tm1.1Kiku/Pla2g5^tm1.1Kiku	involves: 129 * C57BL/6	MGI:5431475

Genotype
MGI:5431475

hm1

• Allelic Composition: Pla2g5^tm1.1Kiku/Pla2g5^tm1.1Kiku
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac muscle contractility ( J:186024 )

• following ischemia and reperfusion, mice exhibit a decreased reduction in fractional shortening compared with wild-type mice

abnormal myocardial fiber physiology ( J:186024 )

• cultured cardiomyocytes treated with hydrogen peroxide exhibit reduced extracellular release of arachidonic acid compared with wild-type cells

abnormal cardiomyocyte apoptosis ( J:186024 )

• following ischemia and reperfusion, mice exhibit a less of an increased apoptosis in the myocardium compared with wild-type mice

abnormal response to cardiac infarction ( J:186024 )

• following ischemia and reperfusion, mice exhibit reduced infarct size, decreased reduction in fractional shortening and less of an increased in apoptosis in the myocardium compared with wild-type mice

• treatment with cPLA2 inhibitors (AACOCF3 and MEFP) is less effective at treating the effects of ischemia and reperfusion than in wild-type mice

decreased myocardial infarct size ( J:186024 )

• following ischemia and reperfusion

homeostasis/metabolism

abnormal response to cardiac infarction ( J:186024 )

• following ischemia and reperfusion, mice exhibit reduced infarct size, decreased reduction in fractional shortening and less of an increased in apoptosis in the myocardium compared with wild-type mice

• treatment with cPLA2 inhibitors (AACOCF3 and MEFP) is less effective at treating the effects of ischemia and reperfusion than in wild-type mice

decreased myocardial infarct size ( J:186024 )

• following ischemia and reperfusion

decreased physiological sensitivity to xenobiotic ( J:186024 )

• treatment with cPLA2 inhibitors (AACOCF3 and MEFP) is less effective at treating the effects of ischemia and reperfusion than in wild-type mice

cellular

abnormal cardiomyocyte apoptosis ( J:186024 )

• following ischemia and reperfusion, mice exhibit a less of an increased apoptosis in the myocardium compared with wild-type mice

muscle

abnormal cardiac muscle contractility ( J:186024 )

• following ischemia and reperfusion, mice exhibit a decreased reduction in fractional shortening compared with wild-type mice

abnormal cardiomyocyte apoptosis ( J:186024 )

• following ischemia and reperfusion, mice exhibit a less of an increased apoptosis in the myocardium compared with wild-type mice